MovDisordV3, France, Analysis, bibRecord, 000263

Brain dopaminergic modulation associated with executive function in Parkinson's disease

Identifieur interne : 000263 ( France/Analysis ); précédent : 000262; suivant : 000264

Brain dopaminergic modulation associated with executive function in Parkinson's disease

Auteurs : Karim Farid [France] ; Igor Sibon [France] ; Dominique Guehl [France] ; Emmanuel Cuny [France] ; Pierre Burbaud [France] ; Michèle Allard [France]

Source :

Movement Disorders [ 0885-3185 ] ; 2009-10-15.

RBID : ISTEX:0C62DB0B5BE49F52ECB956002CAA2B853993A84F

Descripteurs français

Pascal (Inist)
- Encéphale, Fonction exécutive, Imagerie RMN, Maladie de Parkinson, Modulation, Pathologie du système nerveux.

English descriptors

KwdEn :
- Aged, Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Brain (blood supply), Brain (drug effects), Brain (physiopathology), Brain Mapping, Cognition Disorders (drug therapy), Cognition Disorders (etiology), Dopamine (metabolism), Encephalon, Executive Function (drug effects), Executive Function (physiology), Executive function, Female, Humans, Image Processing, Computer-Assisted (methods), Levodopa (pharmacology), Levodopa (therapeutic use), Magnetic Resonance Imaging (methods), Male, Middle Aged, Modulation, Nervous system diseases, Neuropsychological Tests, Nuclear magnetic resonance imaging, Oxygen (blood), Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (pathology), Parkinson disease, Parkinson's disease, dopaminergic cortical modulation, executive function, fMRI.
MESH :
- chemical , blood : Oxygen.
- chemical , metabolism : Dopamine.
- chemical , pharmacology : Antiparkinson Agents, Levodopa.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- blood supply : Brain.
- complications : Parkinson Disease.
- drug effects : Brain, Executive Function.
- drug therapy : Cognition Disorders, Parkinson Disease.
- etiology : Cognition Disorders.
- methods : Image Processing, Computer-Assisted, Magnetic Resonance Imaging.
- pathology : Parkinson Disease.
- physiology : Executive Function.
- physiopathology : Brain.
- Aged, Brain Mapping, Female, Humans, Male, Middle Aged, Neuropsychological Tests.

Abstract

The progressive development of deficits in executive functions, including action planning, is a well‐known complication of Parkinson's disease. A dysfunction of the prefrontal lobe, which is known to be involved in the control of inhibitory processes, could explain the difficulties in initiating behavior or inhibiting ongoing actions in patients with PD. The strong dopaminergic innervation of the prefrontal cortex raises questions about the putative effects of dopa therapy on this cognitive impairment. In the present study, we used fMRI to examine the functional influence of dopa therapy on neural activity during a go/no‐go task in nine patients with and without levodopa treatment and in matched controls. Whereas the patient and control subjects exhibited the same performance during the go/no‐go task, different patterns of brain activation were observed depending on the dopaminergic status. The drug‐off state was characterized by more widely distributed brain activity, mainly in the bilateral caudate. Levodopa did not fully restore normal brain activation and induced changes in the pattern of cingulate cortex activity, which was more pronounced in the rostral part in the drug‐off state and in the caudal part after levodopa intake. These results support the idea of a critical role for dopamine in the control of executive functions in patients with PD. © 2009 Movement Disorder Society

Url:

https://api.istex.fr/document/0C62DB0B5BE49F52ECB956002CAA2B853993A84F/fulltext/pdf

DOI: 10.1002/mds.22709

Affiliations:

France
Bordeaux, Paris

Links to Exploration step

ISTEX:0C62DB0B5BE49F52ECB956002CAA2B853993A84F

Le document en format XML

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<front><div type="abstract" xml:lang="en">The progressive development of deficits in executive functions, including action planning, is a well‐known complication of Parkinson's disease. A dysfunction of the prefrontal lobe, which is known to be involved in the control of inhibitory processes, could explain the difficulties in initiating behavior or inhibiting ongoing actions in patients with PD. The strong dopaminergic innervation of the prefrontal cortex raises questions about the putative effects of dopa therapy on this cognitive impairment. In the present study, we used fMRI to examine the functional influence of dopa therapy on neural activity during a go/no‐go task in nine patients with and without levodopa treatment and in matched controls. Whereas the patient and control subjects exhibited the same performance during the go/no‐go task, different patterns of brain activation were observed depending on the dopaminergic status. The drug‐off state was characterized by more widely distributed brain activity, mainly in the bilateral caudate. Levodopa did not fully restore normal brain activation and induced changes in the pattern of cingulate cortex activity, which was more pronounced in the rostral part in the drug‐off state and in the caudal part after levodopa intake. These results support the idea of a critical role for dopamine in the control of executive functions in patients with PD. © 2009 Movement Disorder Society</div>
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Movement Disorders (revue)

Brain dopaminergic modulation associated with executive function in Parkinson's disease

Brain dopaminergic modulation associated with executive function in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.